Why Migraine and Depression Often Show Up Together
If you live with migraine, you already know it's more than just pain. It can affect your work, your relationships, and your sense of control. But there’s another layer many people don’t expect: the emotional weight that comes with it. Depression is not just common in people with migraine—it's significantly more likely.
Migraine and Depression: A Two-Way Street
A major study led by Dr. Naomi Breslau revealed something striking. People with migraine are more than five times as likely to develop depression. And the reverse is true too: those with depression are three times more likely to develop migraine later on.
This isn’t just a coincidence. Researchers believe these conditions share underlying brain chemistry. Serotonin, dopamine, and norepinephrine—key players in mood regulation—are also involved in how we process pain. When those systems are out of balance, it can affect both your mental health and your migraine frequency.
Chronic Migraine, Higher Risk
The risk of depression increases even more in people with chronic migraine—defined as 15 or more headache days per month. The day-to-day toll adds up:
- Cancelled plans
- Missed work
- Loss of independence
It’s not just the pain. It’s the way pain reshapes your life.
Treating Both, Together
Treating only the physical side of migraine might not be enough. Depression doesn’t always resolve when the headache does. And untreated depression can make migraine worse—or harder to manage.
The good news? You don’t have to treat them separately. Some antidepressants, like duloxetine (Cymbalta), help with both conditions. Cognitive behavioral therapy (CBT) can also address the emotional toll of chronic pain while giving you tools to manage triggers and stress.
If you live with migraine and you’ve felt down more days than not, don’t wait. Talk to a provider who understands both sides of this story.
Disclaimer
This article is for informational purposes only and should not be considered medical advice. If you experience menstrual migraine attacks or other severe headaches, consult your healthcare provider for a proper diagnosis and treatment plan. To explore treatment options, consider booking an appointment with Haven for expert guidance and personalized care.