What Is Calcitonin Gene-Related Peptide (CGRP) and Its Role in Migraines?

Calcitonin gene-related peptide (CGRP) is a neuropeptide produced by neurons in the nervous system, particularly in the trigeminal nerve pathways that innervate blood vessels in the brain and meninges. It was 15 years ago identified as playing a role in the migraine cycle, and when isolated and injected into patients with migraine caused migraine. CGRP acts as a potent vasodilator, promoting widening of blood vessels and contributing to neurogenic inflammation during migraine attacks. Elevated CGRP levels are consistently observed during migraine episodes, making it a key player in migraine pathophysiology. Haven Headache & Migraine Center in San Francisco leverages advanced CGRP-targeted therapies through UCNS-certified specialists, offering virtual care to Orange County patients for effective migraine prevention and relief.​

How CGRP Contributes to Migraine Pathophysiology

CGRP release from trigeminal sensory nerves triggers a cascade during migraines:

• Vasodilation: CGRP relaxes blood vessel walls, leading to cranial vessel dilation that activates pain-sensing nerve fibers.
• Neurogenic Inflammation: It promotes plasma leakage, mast cell degranulation, and release of inflammatory mediators, amplifying pain signals.
• Central Sensitization: CGRP facilitates pain transmission to the brainstem and higher brain centers, worsening headache intensity and sensitivity to light or sound.
• Feedback Loop: Inflammation further stimulates CGRP release, sustaining migraine attacks for hours to days.​

Studies show CGRP levels normalize with successful migraine treatments like triptans, confirming its central role.​

CGRP-Targeted Treatments Revolutionizing Migraine Care

CGRP is the first preventive therapy addressing a biological target of migraine. These modern therapies specifically block CGRP or its receptors:

• Monoclonal Antibodies: Preventive injections (e.g.,erenumab (Aimovig), fremanezumab (Ajovy), galcanezumab (Emgality) (injections), and eptinezumab (Vyepti)bind CGRP or its receptor, reducing monthly migraine days by 50% or more in many patients.
• Gepants: Oral small-molecule antagonists (e.g., rimegepant (Nurtec) or atogepant (Quilpta)) for acute or preventive use, blocking CGRP signaling without vasoconstriction risks.
• Combination Approaches: Specialists integrate CGRP inhibitors with Botox, neuromodulation devices like CEFALY, and lifestyle strategies for optimal results.​

These treatments represent a targeted breakthrough after decades of research.​

Why Choose Haven Headache & Migraine Center for CGRP Therapy?

Haven provides access to:

• UCNS-certified specialists experienced in CGRP-targeted protocols
• Virtual evaluations and personalized treatment plans, including CGRP monoclonal antibodies
• Coordination for in-person injections or infusions in Orange County
• Ongoing monitoring with headache diaries to optimize therapy
• A 5.0-star Google rating for effective, compassionate care

Patients receive comprehensive plans addressing CGRP-driven migraines alongside other headache types.​

Frequently Asked Questions About CGRP and Haven's Services

What triggers CGRP release during migraines?
CGRP release is activated by trigeminal nerve stimulation from migraine triggers like stress, hormones, or sensory stimuli, leading to inflammation and pain.​

Are CGRP therapies safe for long-term use?
Yes, clinical data supports their safety profile, with common side effects limited to injection-site reactions; they avoid cardiovascular risks of older treatments.​

Can Haven prescribe CGRP inhibitors virtually?
Yes, Haven specialists evaluate eligibility and prescribe appropriate CGRP therapies during virtual visits, coordinating local administration as needed.

Which insurances cover CGRP treatments at Haven?
Haven is in-network with major PPO plans, TriCare, Medicare, and Brown & Toland HMOs, with out-of-network options for other HMOs and cash-pay available. Insurance covers CGRP therapy though some require step therapy before being able to access a anti-CGRP therapy.

How soon do CGRP therapies work at Haven?
Many patients notice reduced migraine frequency within 1-3 months, with Haven's monitoring ensuring timely adjustments.

How to Get Started

• Book a Free Intro Call online or by phone
• Complete Your Intake with medical history and symptom details
• Meet Your Specialist virtually within two weeks
• Receive Your Personalized Care Plan including CGRP therapies, lifestyle strategies, and treatment options
• Continue With Ongoing Care through follow-up appointments and adjustments

Unlock Migraine Relief Targeting CGRP

For Orange County, Los Angeles, San Diego, and San Francisco Bay Area patients battling CGRP-mediated migraines, Haven Headache & Migraine Center delivers cutting-edge, accessible care from leading specialists.

Book your consultation today:
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Schedule your appointment with Haven Headache & Migraine Center, providing expert virtual care across California.

Office: (424) 444-7399

Email: 

hello@havenheadache.com

Get personalized care proven to reduce migraine days and restore quality of life. 

Start with a free intro call and discover how Haven helps Orange County patients feel better, faster.