What Does CGRP Do to the Body? Understanding Its Widespread Effects
Calcitonin gene-related peptide (CGRP) functions as a powerful neuropeptide throughout the body, acting as a potent vasodilator, regulator of inflammation, and modulator of pain pathways while also influencing cardiovascular protection, bone metabolism, gastrointestinal motility, and immune responses. In the nervous system, CGRP drives migraine pain through trigeminal nerve activation and neurogenic inflammation. However, systemically, it promotes blood vessel dilation, protects cardiac tissue during stress, stimulates bone formation, and enhances immune cell migration. Haven Headache & Migraine Center in San Francisco expertly manages CGRP's migraine-causing effects with targeted therapies, providing virtual care to Orange County patients through UCNS-certified specialists.
CGRP's Role in the Cardiovascular System
CGRP dilates blood vessels throughout the body, particularly the coronary arteries, thereby reducing blood pressure and protecting the heart from ischemia. It activates receptors on vascular smooth muscle cells, increasing cyclic AMP to relax vessels while inhibiting platelet aggregation. This cardioprotective action makes CGRP valuable in heart failure and hypertension management.
CGRP and Pain/Inflammation Pathways
In sensory nerves, CGRP release from trigeminal and dorsal root ganglia triggers:
- Cranial vasodilation and plasma protein extravasation during migraines
- Neurogenic inflammation amplifying pain signals
- Central sensitization in the brainstem and cortex
- Synergy with substance P to heighten nociception
Elevated CGRP correlates with migraine intensity and associated symptoms like photophobia.
CGRP's Effects on Other Body Systems
CGRP demonstrates diverse physiological roles:
- Bone Metabolism: Stimulates osteoblast activity while inhibiting osteoclasts, maintaining bone density
- Gastrointestinal: Enhances motility, gastric acid secretion, and mucosal protection
- Immune System: Promotes T-cell migration and macrophage chemotaxis from sensory nerves
- Respiratory: Bronchodilation and mucus secretion regulation
- Reproductive: Uterine relaxation during pregnancy
Why Haven Excels at Managing CGRP-Driven Migraines
Haven Headache & Migraine Center offers:
- UCNS-certified specialists skilled in CGRP pathophysiology
- Targeted therapies including monoclonal antibodies and gepants
- Virtual care with Orange County in-person procedure coordination
- Comprehensive monitoring to balance CGRP inhibition benefits vs systemic effects
- Proven 5.0-star Google rating for migraine relief
Specialists tailor treatments recognizing CGRP's dual beneficial and pathological roles.
Frequently Asked Questions About CGRP and Haven's Care
Does blocking CGRP for migraines affect the heart?
Modern CGRP inhibitors show cardiovascular safety in studies, unlike vasoconstrictors, preserving protective vascular effects.
What other conditions involve CGRP besides migraines?
CGRP influences heart disease, osteoporosis, gut motility disorders, and immune responses beyond headache pathology.
Can Haven manage CGRP effects virtually?
Yes, specialists prescribe CGRP-targeted therapies through secure video visits with local administration coordination.
Which plans cover CGRP inhibitors at Haven?
In-network with major PPO plans, TriCare, Medicare, Brown & Toland HMOs; other HMOs via out-of-network, plus cash-pay.
How does Haven monitor CGRP treatment safety?
Regular virtual follow-ups assess efficacy, side effects, and cardiovascular health with personalized adjustments.
How to Get Started
- Book a Free Intro Call online or by phone
- Complete Your Intake with medical history and symptom details
- Meet Your Specialist virtually within two weeks
- Receive Your Personalized Care Plan including CGRP therapies, lifestyle strategies, and treatment options
- Continue With Ongoing Care through follow-up appointments and adjustments
Master CGRP Effects for Migraine Freedom
Orange County patients can harness Haven Headache & Migraine Center's expertise to control CGRP's migraine-triggering effects while preserving its protective roles elsewhere in the body.
Book your consultation today:
Schedule your appointment with Haven Headache & Migraine Center, providing expert virtual care across California.
Office:
Email:
hello@havenheadache.com
Experience targeted care proven to reduce migraine burden while respecting CGRP physiology. Start with a free intro call and discover how Haven helps Orange County patients feel better, faster.