The Role of Stress in Migraine: Why Transitions Matter More Than Stress Levels

Stress is one of the most commonly reported migraine triggers. But it’s not the amount of stress—it’s the transition that often matters most.

The Science Behind Stress and Migraine

When stress levels suddenly change—like when you leave a high-pressure week and finally go on vacation—the brain releases chemicals like PACAP-38, which trigger inflammation and activate migraine pathways.

This explains why so many patients experience attacks at the start of relaxation, not just during busy times.

The Double Burden of Stress and Anxiety

On top of stress transitions, many people with migraine experience:

• Anxiety about the next attack
• Mood changes linked to unpredictable disability
• Comorbid depression or generalized anxiety disorder

This constant cycle is called the interictal burden—the weight migraine patients carry between attacks.

Practical Strategies That Help

At Haven, we teach patients tools to reduce the impact of stress transitions:

• Pain psychology and therapy for coping skills
• Mindfulness and breathwork for nervous system balance
• Medication adjustments during high-risk times (travel, big events)
• Gradual transitions into rest (instead of going from 100% to 0 overnight)

Why This Matters

Managing stress doesn’t mean eliminating it. It means giving your brain the tools to handle change without tipping into an attack.

You can’t avoid every life transition—but with the right plan, you can navigate them with fewer migraine days.

Talk to a Haven provider about building your stress management plan today.