CGRP Inhibitors: The Game-Changer for Migraine Prevention and Relief
CGRP inhibitors represent a breakthrough in migraine treatment by specifically targeting calcitonin gene-related peptide (CGRP), the neuropeptide central to migraine pathophysiology, through monoclonal antibodies and small-molecule receptor antagonists that dramatically reduce attack frequency and severity.
Unlike traditional treatments affecting multiple neurotransmitter systems, CGRP therapies precisely block migraine-triggering inflammation and vasodilation at the molecular level, offering 50%+ reduction in monthly migraine days for many patients.
Haven Headache & Migraine Center in San Francisco delivers these advanced therapies through UCNS-certified specialists via virtual care, providing patients in Orange County, Los Angeles, San Diego, and virtually across California with convenient access to cutting-edge migraine prevention.
How CGRP Inhibitors Work to Stop Migraines
CGRP inhibitors neutralize the peptide or block its receptors in four distinct mechanisms:
- Erenumab binds the CGRP receptor, preventing activation.
- Fremanezumab, galcanezumab, and eptinezumab target the CGRP ligand itself.
- Gepants like rimegepant and ubrogepant provide acute receptor blockade.
These therapies interrupt the trigeminovascular cascade before pain signals reach the brain, preventing attacks rather than merely treating symptoms.
Proven Results from Clinical and Real-World Evidence
Clinical trials demonstrate:
- 50-75% of patients achieve ≥50% reduction in migraine days
- Significant improvement in quality-of-life scores
- Reduced emergency department visits and acute medication overuse
- Rapid onset—benefits often appear within first month of treatment with benefits continuously building over the first 2 eyars
Real-world persistence exceeds 70% at 12 months, confirming sustained effectiveness.
Administration Options for Patient Convenience
CGRP therapies havedelivery options:
- Monthly or quarterly self-administered subcutaneous injections
- Quarterly intravenous infusions (eptinezumab)
- Oral gepants for acute treatment or prevention
Note: not all prevention stratagies are initally available depending on insurance plan
Why Haven Headache & Migraine Center Leads CGRP Therapy
Haven provides comprehensive CGRP management:
- UCNS-certified specialists expert in patient selection and optimization
- Virtual prescriptions with local injection/infusion coordination for Orange County
- Combination protocols integrating CGRP inhibitors with Botox or neuromodulation or other prevention medicaitons
- Continuous virtual monitoring with headache diary analysis
- 5.0-star Google rating reflecting superior patient outcomes
Specialists tailor therapy duration, switching strategies, and combination approaches.
Frequently Asked Questions About CGRP Therapy at Haven
Who qualifies for CGRP inhibitor therapy at Haven?
Adults with episodic (4-14 days/month) or chronic (15+ days/month) migraines failing 2+ prior preventives qualify for evaluation.
How does Haven handle CGRP injection training for patients?
Virtual training sessions plus written/video guides ensure confident self-administration.
Can CGRP therapies treat other headache types besides migraine?
Primarily indicated for migraine/cluster headaches; Haven evaluates all headache disorders for appropriate CGRP candidacy.
What insurance covers CGRP inhibitors through Haven?
In-network with major PPO plans, TriCare, Medicare, HMOs brown and toland and Hill Physicians; out-of-network support provided.
How does Haven transition patients from other preventives to CGRP?
This depends on medication and will be discussed in your a appointment the best strategy for you.
How to Get Started
- Book a Free Intro Call online or by phone
- Complete Your Intake with medical history and symptom details
- Meet Your Specialist virtually within two weeks
- Receive Your Personalized CGRP Therapy Plan with administration training
- Continue With Ongoing Care through virtual follow-ups and optimization
Transform Your Migraine Treatment with CGRP Inhibitors
Orange County patients gain Haven Headache & Migraine Center's specialized expertise, accessing the most effective migraine prevention therapies available today.
Book your consultation today:
Schedule your appointment with Haven Headache & Migraine Center, providing expert virtual care across California.
Office:
Email:
hello@havenheadache.com
Experience CGRP-targeted migraine prevention proven to restore quality of life. Start with a free intro call and discover how Haven helps Orange County patients achieve lasting relief.